High-field gradient permanent micromagnets for targeted drug delivery with magnetic nanoparticles

0365807 - FZÚ 2012 RIV US eng C - Conference Paper (international conference)
Zablotskyy, Vitaliy A. - Pastor, J. M. - Larumbe, S. - Pérez-Landazábal, J.I. - Recarte, V. - Gómez-Polo, C.
High-field gradient permanent micromagnets for targeted drug delivery with magnetic nanoparticles.
8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. Melville: American institute of physics, 2010 - (Häfeli, U.; Schütt, W.; Zborowski, M.), s. 152-157. AIP Conference Proceedings, 1311. ISBN 978-0-7354-0866-1. ISSN 0094-243X.
[International Conference on the Scientific and Clinical Applications of Magnetic Carriers /8./. Rostock (DE), 25.05.2010-29.05.2010]
Institutional research plan: CEZ:AV0Z10100522
Keywords : micromagnets * drug delivery * magnetic nanoparticles
Subject RIV: BM - Solid Matter Physics ; Magnetism
http://link.aip.org/link/?APCPCS/1311/152/1

We analytically investigate several micromagnetic systems aimed at the optimization of drug and gene delivery processes and show their applicability to the controlled positioning of magnetic nanoparticles. The systems considered are: i) a square array of cylindrical microneedles, ii) a planar stepped array of magnets, and iii) a Halbach array of micromagnets. We calculate spatial distributions of force components acting on a magnetic nanoparticle and the field gradients produced by these magnetic configurations. These calculations show that array geometries tend to enhance the field gradients and forces that can be obtained from a given material. The benefits of the proposed micromagnetic systems—tunability, scalability, and ability of creation of magnetic flux distributions with high-gradient areas allowing precise focusing of magnetic nanoparticles (MNPs)—are also discussed.
Permanent Link: http://hdl.handle.net/11104/0200965