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Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
- 1.0365067 - FGÚ 2012 RIV US eng J - Journal Article
Petrenko, N. - Khafizov, K. - Tvrdoňová, Vendula - Skorinkin, A. - Giniatullin, R.
Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor.
Biochemistry. Roč. 50, č. 39 (2011), s. 8427-8436. ISSN 0006-2960
Grant - others:Univerzita Karlova(CZ) 3446/2011
Institutional research plan: CEZ:AV0Z50110509
Keywords : P2X3 * purinergic * ATP * ATP-binding pocket * receptor
Subject RIV: ED - Physiology
Impact factor: 3.422, year: 2011
In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Testing of the S275 mutants using the patch-clamp technice revealed a crucial role for S275 in agonist binding and receptor desensitization
Permanent Link: http://hdl.handle.net/11104/0200403
Number of the records: 1