Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies

0364992 - ÚMCH 2012 RIV NL eng J - Journal Article
Hrubý, Martin - Škodová, Michaela - Macková, Hana - Skopal, Jan - Tomeš, Marek - Kropáček, Martin - Zimová, Jana - Kučka, Jan
Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies.
Reactive and Functional Polymers. Roč. 71, č. 12 (2011), s. 1155-1159. ISSN 1381-5148. E-ISSN 1873-166X
R&D Projects: GA ČR GPP207/10/P054; GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z10480505
Keywords : macroporous chelating beads * radioembolization * quinoline-8-ol
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.479, year: 2011

We describe the synthesis, characterization and radiochemical studies on macroporous chelating polymer beads as carriers of beta-emitters lutetium-177 and iodine-131 intended for radioembolization of liver tumors. All the polymers were labeled quantitatively by lutetium-177 in ammonium acetate buffer, DOTA containing beads however required heating to 80 °C while the quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties containing polymers were quantitatively radiolabeled within 1 h at room temperature. The quinoline-8-ol groups containing polymer was radioiodinated in 95% yield by a chloramine method. Both lutetium-177 and iodine-131 radiolabels were stable in an in vitro study in rat blood plasma. Quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties are thus more suitable for the radiolabeling of macroporous beads with lutetium-177 for radioembolization purposes than well-established DOTA.
Permanent Link: http://hdl.handle.net/11104/0006574