Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

0364901 - BC 2012 RIV GB eng J - Journal Article
Weidmann, M. - Růžek, Daniel - Křivanec, K. - Zoeller, G. - Essbauer, S. - Pfeffer, M. - Zanotto, P. M. de A. - Hufert, F.T. - Dobler, G.
Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe.
Journal of General Virology. Roč. 92, Part 8 (2011), 1906-1916. ISSN 0022-1317. E-ISSN 1465-2099
R&D Projects: GA ČR GPP302/10/P438; GA ČR GAP502/11/2116; GA MŠMT(CZ) LC06009
Institutional research plan: CEZ:AV0Z60220518
Keywords : IXODES-RICINUS * NATURAL FOCI * ROE DEER * ENDEMIC AREA * RUSSIA * FLAVIVIRUSES * EVOLUTION * VECTOR * SWEDEN * JAPAN
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.363, year: 2011

Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic (CR), and 4 isolates and 9 TBEV strains detected in ticks from Germany (1954 to 2009), were sequenced and subjected to phylogenetic and Bayesian phylodynamic. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the CR that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8x10(-4) substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Zd'ar Kaplice proved for the first time that TBEV is indeed subject to local evolution.
Permanent Link: http://hdl.handle.net/11104/0200264