Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

0364802 - BC 2012 RIV GB eng J - Journal Article
Alfonzo, J. D. - Lukeš, Julius
Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors.
Trends in Parasitology. Roč. 27, č. 6 (2011), 234-237. ISSN 1471-4922. E-ISSN 1471-5007
R&D Projects: GA MŠMT LC07032; GA MŠMT 2B06129; GA ČR GA204/09/1667
Institutional research plan: CEZ:AV0Z60220518
Keywords : IRON-SULFUR CLUSTERS * TRYPANOSOMA-BRUCEI * MITOCHONDRIAL * PROTEIN * FRATAXIN * BIOSYNTHESIS * SYNTHETASES * BIOGENESIS * THIOLATION * ANTICODON
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.144, year: 2011

Trypanosome brucei undergoes two clearly distinct develomental stages: in the insect vector (procyclic stage) the cells generate the bulk of their energy through respiration, whereas in the bloodstream of the mammalian host (bloodstream stage) they grow mostly glycolytically. Several mitochondrial respiratory proteins require iron-sulfur clusters for activity, and their activation coincides with developmental changes. Likewise some tRNA modification enzymes either require iron-sulfur clusters or use components of the iron-sulfur cluster assembly pathway for activity. These enzymes affect the anticodon loop of various tRNAs and can impact protein synthesis. Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined.
Permanent Link: http://hdl.handle.net/11104/0200186