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Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus
- 1.0364792 - FGÚ 2012 RIV US eng J - Journal Article
Zemková, Hana - Stojilkovič, S.S. - Klein, D. C.
Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus.
Endocrinology. Roč. 152, č. 10 (2011), s. 3842-3851. ISSN 0013-7227. E-ISSN 1945-7170
R&D Projects: GA ČR(CZ) GA305/07/0681
Institutional research plan: CEZ:AV0Z50110509
Keywords : Ca2plus-activated Kplus channels * voltage-gated Ca2plus channels * electrical activity * pinealocyte
Subject RIV: ED - Physiology
Impact factor: 4.459, year: 2011
The pineal gland is a neuroendocrine transducer, which generates a nocturnal increase in melatonin production, reflecting stimulation by norepinephrine (NE). NE was found to act through alpha1B-adrenoreceptors in a concentration-dependent manner to produce a biphasic change in membrane potential: initial transient hyperpolarization is followed by stable depolarization. These observations indicate that both continuous elevation of intracellular Ca2plus and sustained depolarization are associated with and are likely to be required for activation of the pinealocyte
Permanent Link: http://hdl.handle.net/11104/0200178
Number of the records: 1