Fibrinogen-related proteins in ixodid ticks

0364780 - BC 2012 RIV GB eng J - Journal Article
Štěrba, J. - Dupejová, J. - Fišer, M. - Vancová, Marie - Grubhoffer, Libor
Fibrinogen-related proteins in ixodid ticks.
Parasites & Vectors. Roč. 4, - (2011), e127. ISSN 1756-3305. E-ISSN 1756-3305
R&D Projects: GA MŠMT(CZ) LC06009; GA AV ČR KJB600960906; GA ČR GA206/09/1782
Institutional research plan: CEZ:AV0Z60220518
Keywords : AMERICAN DOG TICK * INNATE IMMUNITY * DORIN-M * RHIPICEPHALUS-APPENDICULATUS * MOLECULAR CHARACTERIZATION * DERMACENTOR-VARIABILIS * ORNITHODOROS-MOUBATA * LECTINS * HEMOLYMPH * BINDING
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.937, year: 2011
http://www.parasitesandvectors.com/content/pdf/1756-3305-4-127.pdf

Fibrinogen-related proteins with lectin activity are believed to be part of the tick innate immune system. Some of them were detected in high abundance in the haemolymph of ixodid ticks Dermacentor marginatus, Rhipicephalus appendiculatus, R. pulchellus, and R. sanguineus. These proteins were recognised by sera directed against the tick lectin Dorin M and the haemagglutination activity of the ticks R. appendiculatus and D. marginatus. The fibrinogen-related proteins were shown to be glycosylated and they were localised in salivary glands, midguts, and haemocytes of D. marginatus. The detected proteins have potential as targets for anti-tick vaccines and as antimicrobial proteins in pharmacology.
Permanent Link: http://hdl.handle.net/11104/0200167