Unique exposure system for the whole body inhalation experiments with small animals

0364771 - ÚIACH 2012 RIV CZ eng C - Conference Paper (international conference)
Večeřa, Zbyněk - Mikuška, Pavel - Dočekal, Bohumil - Vojta, Šimon - Míšek, Ivan - Moravec, Pavel - Smolík, Jiří
Unique exposure system for the whole body inhalation experiments with small animals.
NANOCON 2011. Conference Proceedings. Ostrava: Tanger Ltd, 2011, s. 1-3. ISBN 978-80-87294-23-9.
[NANOCON 2011. International Conference /3./. Brno (CZ), 21.09.2011-23.09.2011]
R&D Projects: GA ČR(CZ) GAP503/11/2315
Institutional research plan: CEZ:AV0Z40310501; CEZ:AV0Z40720504; CEZ:AV0Z50450515
Keywords : inhalation chamber * chronic exposure studies of small animals * long-term inhalation procedures
Subject RIV: CB - Analytical Chemistry, Separation

The especially inhalation chamber is constructed for chronic exposure studies of small animals to nanoparticles under strictly controlled conditions in frame of project „Study of transport of inhalated nano-sized particles (Pb, Cd) and their allocation in organs“. The inhalation chamber builds from a glass and stainless steel and makes possible long-term inhalation procedures (up to 60 days, 24 hours/day) with up to four discrete groups of mice population (up to 60 individuals each) or of rats population (up to 20 individuals each) under controlled illumination, temperature, relative humidity, doses (0.5 x 106 - 5 x 106 particles/cm3) and size (10-60 nm) of nano-sized particles which are synthesized via aerosol route in a hot wall tube flow reactor using metal organic precursors.
Permanent Link: http://hdl.handle.net/11104/0200160