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Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells
- 1.0364720 - FGÚ 2012 RIV US eng J - Journal Article
Vagnerová, Karla - Loukotová, Jana - Ergang, Peter - Musílková, Jana - Mikšík, Ivan - Pácha, Jiří
Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells.
Steroids. Roč. 76, č. 6 (2011), s. 577-581. ISSN 0039-128X. E-ISSN 1878-5867
R&D Projects: GA ČR(CZ) GAP303/10/0969
Institutional research plan: CEZ:AV0Z50110509
Keywords : 11beta-hydroxysteroid dehydrogenase * thiazolidinediones
Subject RIV: ED - Physiology
Impact factor: 2.829, year: 2011
The study demonstrates that activation of PPARgamma in vascular smooth muscle cells up-regulates vascular 11HSD1and thus reactivates 11-oxo metabolites to biologically active glucocorticoids. The data provide one of the possible explanations for PPARgamma-agonist’s effects on the cardiovascular system
Permanent Link: http://hdl.handle.net/11104/0200126
Number of the records: 1