Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling

0364583 - ÚEM 2012 RIV GB eng J - Journal Article
Charles, C. - Hovořáková, Mária - Ahn, Y. - Lyons, D. B. - Marangoni, P. - Churavá, Svatava - Biehs, B. - Jheon, A. - Lesot, H. - Balooch, G. - Krumlauf, R. - Viriot, L. - Peterková, Renata - Klein, O. D.
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
Development. Roč. 138, č. 18 (2011), s. 4063-4073. ISSN 0950-1991. E-ISSN 1477-9129
R&D Projects: GA ČR GA304/09/1579; GA ČR GA304/07/0223
Institutional research plan: CEZ:AV0Z50390512
Keywords : FGF signaling * Sprouty genes * Incisor
Subject RIV: EA - Cell Biology
Impact factor: 6.596, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0364583_01.pdf

In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway.
Permanent Link: http://hdl.handle.net/11104/0200032