Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study

0364530 - ÚOCHB 2012 RIV DE eng J - Journal Article
Čeřovský, Václav - Slaninová, Jiřina - Fučík, Vladimír - Monincová, Lenka - Bednárová, Lucie - Maloň, Petr - Štokrová, Jitka
Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study.
Chembiochem. Roč. 12, č. 9 (2011), s. 1352-1361. ISSN 1439-4227. E-ISSN 1439-7633
R&D Projects: GA ČR GA203/08/0536
Institutional research plan: CEZ:AV0Z40550506
Keywords : antimicrobial peptide * disulfide bridge * lucifensin * solid phase synthesis
Subject RIV: CC - Organic Chemistry
Impact factor: 3.944, year: 2011

Lucifensin, a novel insect defensin of medicinal maggots identified recently in our laboratory, is 40 amino acid residues and three intramolecular bridges peptide. Oxidative folding of linear lucifensin precursor prepared by solid phase peptide synthesis resulted in a peptide with a pattern of disulfide bridges identical to that of native lucifensin. Synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. The presence of disulfide bridges and the N-terminal part of its molecule for the structure and antimicrobial activity is essential.
Permanent Link: http://hdl.handle.net/11104/0199997