Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids

0364489 - FGÚ 2012 RIV DE eng J - Journal Article
Flachs, Pavel - Rühl, R. - Hensler, Michal - Janovská, Petra - Zouhar, Petr - Kůs, Vladimír - Macek Jílková, Zuzana - Papp, E. - Kuda, Ondřej - Svobodová, Michaela - Rossmeisl, Martin - Tsenov, Grygoriy - Mohamed-Ali, V. - Kopecký, Jan
Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids.
Diabetologia. Roč. 54, č. 10 (2011), s. 2626-2638. ISSN 0012-186X. E-ISSN 1432-0428
R&D Projects: GA MŠMT(CZ) 1M0520; GA ČR(CZ) GA303/08/0664
Institutional research plan: CEZ:AV0Z50110509
Keywords : 15-Deoxy-Delta(12,15)-prostaglandin J(2) * DHA * EPA * fish oil * white adipose tissue * metabolic syndrome
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 6.814, year: 2011

White adipose tissue plays an active role in the amelioration of obesity and the improvement of glucose homeostasis by combining LC n-3 PUFA intake and calorie restriction in mice fed high-fat diet. Specifically in the epididymal fat in the abdomen, but not in other fat depots, synergistic induction of mitochondrial oxidative capacity and lipid catabolism was observed, resulting in increased oxidation of metabolic fuels in the absence of mitochondrial uncoupling, while low-grade inflammation was suppressed, reflecting changes in tissue levels of anti-inflammatory lipid mediators, namely 15-Deoxy-∆12,15-prostaglandin J2 and protectin D1
Permanent Link: http://hdl.handle.net/11104/0199963