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Oxidized Phosphatidylcholines Facilitate Phospholipid Flip-Flop in Liposomes
- 1.0364475 - ÚOCHB 2012 RIV US eng J - Journal Article
Volinsky, R. - Cwiklik, Lukasz - Jurkiewicz, Piotr - Hof, Martin - Jungwirth, Pavel - Kinnunen, P. K. J.
Oxidized Phosphatidylcholines Facilitate Phospholipid Flip-Flop in Liposomes.
Biophysical Journal. Roč. 101, č. 6 (2011), s. 1376-1384. ISSN 0006-3495. E-ISSN 1542-0086
R&D Projects: GA MŠMT LC512; GA MŠMT(CZ) LC06063; GA ČR GA203/08/0114; GA AV ČR GEMEM/09/E006
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z40400503
Keywords : lipid oxidation * fluorescence spectroscopy * molecular dynamics
Subject RIV: CC - Organic Chemistry
Impact factor: 3.653, year: 2011
A combination of fluorescence spectroscopy and molecular dynamics simulations reveal that phospholipid oxidation results in a fast cross bilayer diffusion of membrane phospholipids and loss of lipid asymmetry.
Permanent Link: http://hdl.handle.net/11104/0199954
Number of the records: 1