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Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery

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    0364301 - FGÚ 2012 RIV NL eng J - Journal Article
    Líšková, Silvia - Petrová, M. - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
    Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery.
    European Journal of Pharmacology. Roč. 667, 1-3 (2011), s. 265-270. ISSN 0014-2999. E-ISSN 1879-0712
    R&D Projects: GA ČR(CZ) GA305/09/0336; GA AV ČR(CZ) IAA500110902
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : EDCF * SHR * norepinephrine * L-NNA * indomethacin
    Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
    Impact factor: 2.516, year: 2011

    Endothelium-dependent contraction elicited by high concentrations of acetylcholine was described in hypertensive as well as in aged normotensive rats. The contribution of endothelium-derived constricting factor (EDCF) to norepinephrine-induced contraction is still unknown. We aimed to compare EDCF participation to norepinephrine-induced arterial contraction in spontaneously hypertensive rats (SHR) and aged normotensive Wistar-Kyoto (WKY) rats. We conclude that EDCF contribution to norepinephrine-induced contraction of conduit arteries is similarly enhanced in adult hypertensive and aged normotensive rats
    Permanent Link: http://hdl.handle.net/11104/0199821

     
     
Number of the records: 1  

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