Altered neural and vascular mechanisms in hypertension

0364294 - FGÚ 2012 RIV CZ eng J - Journal Article
Pintérová, Mária - Kuneš, Jaroslav - Zicha, Josef
Altered neural and vascular mechanisms in hypertension.
Physiological Research. Roč. 60, č. 3 (2011), s. 381-402. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/09/0336
Institutional research plan: CEZ:AV0Z50110509
Keywords : adrenoceptors * G proteins * L-type voltage-dependent calcium channels * potassium channels * RhoA/Rho kinase * genetic hypertension
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.555, year: 2011

This review is focused on two major antagonistic players in the regulation of blood pressure, i.e. sympathetic nervous system (by stimulation of adrenoceptors coupled to stimulatory and inhibitory G proteins) and nitric oxide (by cGMP signaling pathway), elicit their actions via the control of calcium influx through L-VDCC. However, L-type calcium current can also be regulated by the changes in membrane potential elicited by the activation of potassium channels, the impaired function of which was detected in hypertensive animals. The dominant role of enhanced calcium influx in the pathogenesis of high blood pressure of genetically hypertensive animals is confirmed not only by therapeutic efficacy of calcium antagonists but especially by the absence of hypertension in animals in which L-type calcium current was diminished by pertussis toxin-induced inactivation of inhibitory G proteins
Permanent Link: http://hdl.handle.net/11104/0199815