Genetic control of resistance to Trypanosoma brucei brucei infection in mice

0363620 - ÚMG 2012 RIV US eng J - Journal Article
Šíma, Matyáš - Havelková, Helena - Quan, L. - Svobodová, M. - Jarošíková, T. - Vojtíšková, Jarmila - Stassen, A. P. M. - Demant, P. - Lipoldová, Marie
Genetic control of resistance to Trypanosoma brucei brucei infection in mice.
PLoS Neglected Tropical Diseases. Roč. 5, č. 6 (2011), e1173. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA AV ČR IAA500520606; GA MŠMT(CZ) LC06009
Grant - others:NIH-NCI(US) 1R01CA127162-01
Institutional research plan: CEZ:AV0Z50520514
Keywords : Trypanosoma brucei brucei * mouse recombinant congenic strains * Tbbr
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.716, year: 2011

Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes.
Permanent Link: http://hdl.handle.net/11104/0199369