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6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs
- 1.0363423 - ÚOCHB 2012 RIV NL eng J - Journal Article
de Jersey, J. - Holý, Antonín - Hocková, Dana - Naesens, L. - Keough, D. T. - Guddat, L. W.
6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs.
Current Topics in Medicinal Chemistry. Roč. 11, č. 16 (2011), s. 2085-2102. ISSN 1568-0266. E-ISSN 1873-4294
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : Malaria * acyclic nucleoside phosphonates * hypoxanthine * guanine phosphoribosyl transferase
Subject RIV: CC - Organic Chemistry
Impact factor: 4.174, year: 2011
Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates. The focus of this review is on the identification and characterization of inhibitors of the key enzyme in this pathway - 6-oxopurine phosphoribosyltransferase. The acyclic nucleoside phosphonates (ANPs) appear to be excellent candidates that can be selective compared to the human enzyme.
Permanent Link: http://hdl.handle.net/11104/0006532
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