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The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction
- 1.0363154 - ÚOCHB 2012 RIV GB eng J - Journal Article
Břehová, Petra - Česnek, Michal - Dračínský, Martin - Holý, Antonín - Janeba, Zlatko
The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction.
Tetrahedron. Roč. 67, č. 38 (2011), s. 7379-7385. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : Liebeskind-Srogl cross-coupling * acyclic nucleoside phosphonates * pyrimidines * arylboronic acids * microwave
Subject RIV: CC - Organic Chemistry
Impact factor: 3.025, year: 2011
A series of novel acyclic nucleoside phosphonates with various aryls attached to the C-2 position of the pyrimidine moiety has been prepared using the Liebeskind-Srogl cross-coupling protocol. The reactions of highly functionalised 2-(methylsulfanyl)pyrimidines with various arylboronic acids were studied and optimised.
Permanent Link: http://hdl.handle.net/11104/0199214
Number of the records: 1