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Regioselective alcoholysis of silybin A and B acetates with lipases
- 1.0363054 - MBÚ 2012 RIV NL eng J - Journal Article
Purchartová, Kateřina - Marhol, Petr - Gažák, Radek - Monti, D. - Riva, S. - Kuzma, Marek - Křen, Vladimír
Regioselective alcoholysis of silybin A and B acetates with lipases.
Journal of Molecular Catalysis B-Enzymatic. Roč. 71, 3-4 (2011), s. 119-123. ISSN 1381-1177
R&D Projects: GA MŠMT OC09045; GA MŠMT(CZ) ME10027; GA ČR(CZ) GAP301/11/0767
Institutional research plan: CEZ:AV0Z50200510
Keywords : Silybin B * Silibinin * Silymarin
Subject RIV: CC - Organic Chemistry
Impact factor: 2.735, year: 2011
Large screening identified lipase AK to be capable of the selective deacetylation of pentaacetyl silybins A and B to yield 3,5,20,23-tetra-O-acetyl-silybins A and B, and 3,20,23-tri-O-acetyl-silybins A and B, respectively. Deacetylation occurred at phenolic OH groups, only. These new compounds prepared from the optically pure silybins can serve as new stereochemically pure synthons for selective silybin modifications
Permanent Link: http://hdl.handle.net/11104/0199161
Number of the records: 1