Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

0363004 - MBÚ 2012 RIV GB eng J - Journal Article
Kverka, Miloslav - Zákostelská, Zuzana - Klimešová, Klára - Sokol, Dan - Hudcovic, Tomáš - Hrnčíř, Tomáš - Rossmann, Pavel - Mrázek, Jakub - Kopečný, Jan - Verdu, E. - Tlaskalová-Hogenová, Helena
Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition.
Clinical and Experimental Immunology. Roč. 163, č. 2 (2011), s. 250-259. ISSN 0009-9104. E-ISSN 1365-2249
R&D Projects: GA AV ČR KJB500200904; GA AV ČR 1QS500200572; GA AV ČR IAA5020205; GA ČR GD310/08/H077; GA ČR GA303/08/0367; GA ČR GA305/08/0535
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z50450515
Keywords : animal models * cytokines/interleukins * DSS colitis
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.360, year: 2011

Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology
Permanent Link: http://hdl.handle.net/11104/0199146