Mitochondrially targeted anti-cancer agents

0361635 - BTÚ 2012 RIV GB eng J - Journal Article
Biasutto, L. - Dong, L.A. - Zoratti, M. - Neužil, Jiří
Mitochondrially targeted anti-cancer agents.
Mitochondrion. Roč. 10, č. 6 (2010), s. 670-681. ISSN 1567-7249. E-ISSN 1872-8278
Institutional research plan: CEZ:AV0Z50520701
Keywords : Mitochondrial targeting * pro-oxidant effect * reactive oxygen species
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.238, year: 2010

Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification of such structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance
Permanent Link: http://hdl.handle.net/11104/0198905