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Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel diseases
- 1.0361618 - MBÚ 2012 RIV CZ eng J - Journal Article
Drastich, P. - Frolová-Břízová, Lenka - Zanvit, P. - Špičák, J. - Tlaskalová-Hogenová, Helena
Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel diseases.
Folia Microbiologica. Roč. 56, č. 3 (2011), 185-190. ISSN 0015-5632. E-ISSN 1874-9356
R&D Projects: GA AV ČR 1QS500200572; GA ČR GA305/08/0535; GA ČR GD310/08/H077; GA MŠMT 2B06155
Institutional research plan: CEZ:AV0Z50200510
Keywords : NECROSIS-FACTOR-ALPHA * ULCERATIVE-COLITIS * CROHNS-DISEASE
Subject RIV: EC - Immunology
Impact factor: 0.677, year: 2011
Interleukin-6 (IL-6) plays an important role in regulation of intestinal inflammatory processes in inflammatory bowel disease (IBD). The levels of IL-6 in media from cultured biopsy samples were determined by ELISA in 14 Crohn’s disease (CD) patients, 17 patients with ulcerative colitis (UC), and 24 healthy controls in terminal ileum, cecum, and rectum. Results were confirmed by measuring mRNA expression in selected patients. In CD patients, there were increased levels of IL-6 (expressed in picograms per milligram of biopsy tissue mass) in terminal ileum compared with controls
Permanent Link: http://hdl.handle.net/11104/0198895
Number of the records: 1