Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level

0361510 - ÚOCHB 2012 RIV PL eng J - Journal Article
Nosáľ, R. - Perečko, T. - Jančinová, V. - Drábiková, K. - Harmatha, Juraj - Sviteková, K.
Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level.
Pharmacological Reports. Roč. 63, č. 3 (2011), s. 790-798. ISSN 1734-1140. E-ISSN 2299-5684
R&D Projects: GA ČR(CZ) GA203/07/1227
Institutional research plan: CEZ:AV0Z40550506
Keywords : neutrophils * N-feruloylserotonin * extracellular and intracellular chemiluminescence
Subject RIV: CC - Organic Chemistry
Impact factor: 2.445, year: 2011

N-feruloylserotonin (N-f-5HT) isomers, isolated from seeds of Leuzea carthamoides, inhibited dose-dependent oxidative burst in human whole blood and isolated neutrophils in vitro, which were measured by luminol-and/or isoluminol-enhanced chemiluminescence. The results suggest that N-f-5HT isomers are an effective, naturally occurring substances with a potent pharmacological effect on the oxidative burst of human neutrophils.
Permanent Link: http://hdl.handle.net/11104/0198810