Role of Intestinal Bacteria in Gliadin-Induced Changes in Intestinal Mucosa: Study in Germ-Free Rats

0360844 - MBÚ 2012 RIV US eng J - Journal Article
Cinová, Jana - De Palma, G. - Štěpánková, Renata - Kofroňová, Olga - Kverka, Miloslav - Sanz, Y. - Tučková, Ludmila
Role of Intestinal Bacteria in Gliadin-Induced Changes in Intestinal Mucosa: Study in Germ-Free Rats.
PLoS ONE. Roč. 6, č. 1 (2011), s. 1-10. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR GA310/07/0414; GA ČR GA303/08/0367; GA ČR GPP304/10/P406; GA AV ČR IAA500200801; GA AV ČR IAA500200710; GA AV ČR KJB500200904; GA MŠMT 2B06155
Institutional research plan: CEZ:AV0Z50200510
Keywords : CELIAC-DISEASE * ALTERED EXPRESSION * MATRIX METALLOPROTEINASES
Subject RIV: EC - Immunology
Impact factor: 4.092, year: 2011

Background and Aims: Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically predisposed individuals. The overgrowth of potentially pathogenic bacteria and infections has been suggested to contribute to CD pathogenesis. We aimed to study the effects of gliadin and various intestinal bacterial strains on mucosal barrier integrity, gliadin translocation, and cytokine production
Permanent Link: http://hdl.handle.net/11104/0198300