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Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces

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    0360787 - ÚMCH 2012 RIV DE eng J - Journal Article
    Rodriguez-Emmenegger, Cesar Adolfo - Brynda, Eduard - Riedel, Tomáš - Houska, Milan - Šubr, Vladimír - Bologna Alles, A. - Hasan, E. - Gautrot, J. E. - Huck, W. T. S.
    Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces.
    Macromolecular Rapid Communications. Roč. 32, č. 13 (2011), s. 952-957. ISSN 1022-1336. E-ISSN 1521-3927
    R&D Projects: GA AV ČR KAN200670701; GA AV ČR IAAX00500803
    Institutional research plan: CEZ:AV0Z40500505
    Keywords : biosensors * blood plasma * HPMA
    Subject RIV: CD - Macromolecular Chemistry
    Impact factor: 4.596, year: 2011

    Ultra-low-fouling poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes have been synthesized for the first time. Similar to the so far only ultra-low-fouling surface, poly(carboxybetaine acrylamide), the level of blood plasma fouling was below the detection limit of surface plasmon resonance (SPR, 0.03 ng • cm−2) despite being a hydrogen bond donor and displaying a moderate wettability, thus challenging the currently accepted views for the design of antifouling properties. The antifouling properties were preserved even after two years of storage. To demonstrate the potential of poly(HPMA) brushes for the preparation of bioactive ultra-low fouling surfaces a label-free SPR immunosensor for detection of G Streptococcus was prepared.
    Permanent Link: http://hdl.handle.net/11104/0198254

     
     
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