Number of the records: 1
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines
- 1.0360740 - ÚOCHB 2012 RIV GB eng J - Journal Article
Baszczyňski, Ondřej - Jansa, Petr - Dračínský, Martin - Klepetářová, Blanka - Holý, Antonín - Votruba, Ivan - De Clercq, E. - Balzarini, J. - Janeba, Zlatko
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Bioorganic & Medicinal Chemistry. Roč. 19, č. 7 (2011), s. 2114-2124. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * purines * FPMP * antiviral * N6-Methyl-AMP aminohydrolase
Subject RIV: CC - Organic Chemistry
Impact factor: 2.921, year: 2011
An efficient method for the synthesis of N9-[3-fluoro-2-(phosphonomethoxy)propyl] (FPMP) derivatives of purine bases has been developed. Several FPMPDAP derivatives had a moderate antiretroviral activity.
Permanent Link: http://hdl.handle.net/11104/0198222
Number of the records: 1