Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

0360713 - MBÚ 2012 RIV CH eng J - Journal Article
Bojarová, Pavla - Křen, Vladimír
Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short.
Chimia. Roč. 65, 1-2 (2011), 64-70. ISSN 0009-4293. E-ISSN 0009-4293
R&D Projects: GA ČR GP203/09/P024; GA MŠMT(CZ) LC06010; GA MŠMT OC09045
Institutional research plan: CEZ:AV0Z50200510
Keywords : Carbohydrate * Enzymatic synthesis * Glycosidase
Subject RIV: CC - Organic Chemistry
Impact factor: 1.212, year: 2011

Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosacharide synthesis catalyzed by glycosidases represents an elegant way to komplex carbohydrate structures. Two approaches to glycosidase catalysis are presented: i) the use of structurally modified substrates that carry various functional moieties in the molecule, and ii) the design of mutant glycosidases void of hydrolytic activity. Products of glycosidase catalyzed synthesis are applicable in a range of areas such as immunology, therapy of Alzheimer’s or Parkinson’s diseases and the synthesis of neoglycoproteins
Permanent Link: http://hdl.handle.net/11104/0198199