Factors affecting the frequency of micronuclei in asthmatic and healthy children from Ostrava

0360459 - ÚEM 2012 RIV NL eng J - Journal Article
Rössnerová, Andrea - Špátová, Milada - Rössner ml., Pavel - Nováková, Zuzana - Solanský, I. - Šrám, Radim
Factors affecting the frequency of micronuclei in asthmatic and healthy children from Ostrava.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 708, č. 12 (2011), s. 44-49. ISSN 0027-5107
R&D Projects: GA MŽP(CZ) SP/1B3/8/08
Institutional research plan: CEZ:AV0Z50390512
Keywords : air pollution * asthma * automated image analysis
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 2.850, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0360459_01.pdf

Anotace A.: The aim of the study was to analyze the effect of age, gender, smoking, vitamin intake, genetic polymorphism in genes related to the metabolic activation of PAHs and their detoxification and oxidative damage to DNA, lipids and protein on the frequency of micronuclei (MN). The study group consisted of 175 children aged 6-15 years (81 with asthma, 94 healthy controls; 15 children were active smokers) from Ostrava, Czech Republic. The frequency of MN/1000 BNC, measured by automated image analysis, indicated a significant risk of DNA damage for smoking children with asthma in comparison with smoking control children.
Permanent Link: http://hdl.handle.net/11104/0198010