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Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing
- 1.0360303 - BFÚ 2012 RIV US eng J - Journal Article
Crhák Khaitová, Lucie - Fojtová, M. - Křížová, Kateřina - Lunerová Bedřichová, Jana - Fulneček, Jaroslav - Depicker, A. - Kovařík, Aleš
Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing.
Epigenetics. Roč. 6, č. 5 (2011), s. 650-660. ISSN 1559-2294. E-ISSN 1559-2308
R&D Projects: GA ČR(CZ) GD204/09/H002; GA MŠMT(CZ) LC06004
Grant - others:GA ČR(CZ) GPP501/11/P667
Program: GP
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : transcriptional gene silencing * transgene epialleles * DNA methylation
Subject RIV: BO - Biophysics
Impact factor: 4.318, year: 2011
In this work we show that the sensitivity of transgene loci to inherited silencing (paramutation) induced in trans by small RNA molecules depends on the structure and epigenetic state of target. The complex inverted repeat loci with methylation in the coding region are generally more sensitive than single copy insertions.
Permanent Link: http://hdl.handle.net/11104/0197884
Number of the records: 1