Subspecific origin and haplotype diversity in the laboratory mouse

0360034 - ÚBO 2012 RIV US eng J - Journal Article
Yang, H. - Wang, J. R. - Didion, J. P. - Buus, R. J. - Bell, T. A. - Welsh, C. E. - Bonhomme, F. - Yu, A. H.-T. - Nachman, M. W. - Piálek, Jaroslav - Tucker, P. - Boursot, P. - McMillan, L. - Churchill, G. A. - de Villena, F. P.
Subspecific origin and haplotype diversity in the laboratory mouse.
Nature Genetics. Roč. 45, č. 7 (2011), s. 648-655. ISSN 1061-4036. E-ISSN 1546-1718
R&D Projects: GA ČR GA206/08/0640
Institutional research plan: CEZ:AV0Z60930519
Keywords : inbred strains * house mice * resource * genome * genes * SNPS
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 35.532, year: 2011

Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process.
Permanent Link: http://hdl.handle.net/11104/0197683