Age-dependent remodelling of ionotropic signalling in cortical astroglia

0359954 - ÚEM 2012 RIV US eng J - Journal Article
Lalo, U. - Palygin, O. - North, R. A. - Verkhratsky, Alexei - Pankratov, Y.
Age-dependent remodelling of ionotropic signalling in cortical astroglia.
Aging Cell. Roč. 10, č. 3 (2011), s. 392-402. ISSN 1474-9718. E-ISSN 1474-9726
R&D Projects: GA ČR GA305/08/1384
Institutional research plan: CEZ:AV0Z50390703
Keywords : astrocytes * aging * synaptic transmission
Subject RIV: FH - Neurology
Impact factor: 6.265, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0359954_01.pdf

Here, we demonstrated marked age-dependent changes in ionotropic receptors (AMPA, P2X and NMDA) in astrocytes and their role in GSCs generation. Our results demonstrate that fast synaptic transmission between neurones and astrocytes in neocortex that may be involved in information processing in neuronal-glial networks undergoes remodelling during brain maturation and aging.
Permanent Link: http://hdl.handle.net/11104/0197627