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Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis

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    0359445 - FGÚ 2012 RIV US eng J - Journal Article
    Pravenec, Michal - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Šilhavý, J. - Maxová, M. - Kazdová, L. - Seidman, J. G. - Seidman, Ch. E. - Eminaga, S. - Gorham, J. - Wang, J. - Kurtz, T. W.
    Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.
    Physiological Genomics. Roč. 43, č. 7 (2011), s. 372-379. ISSN 1094-8341. E-ISSN 1531-2267
    R&D Projects: GA MŠMT(CZ) ME08006; GA MŠMT(CZ) 1M0510; GA AV ČR(CZ) IAA500110805; GA MZd(CZ) NS9759
    Grant - others:Fondation Leducq(FR) 06CVD03
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : transgenic rat * adipose tissue * insulin resistance * autocrine effects
    Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
    Impact factor: 2.735, year: 2011

    We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue
    Permanent Link: http://hdl.handle.net/11104/0197234

     
     
Number of the records: 1  

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