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Japanese encephalitis virus: from genome to infectome
- 1.0359440 - BC 2012 RIV NL eng J - Journal Article
Unni, S. K. - Růžek, Daniel - Chhatbar, C. - Mishra, R. - Johri, M. K. - Singh, S. K.
Japanese encephalitis virus: from genome to infectome.
Microbes and Infection. Roč. 13, č. 4 (2011), 312-321. ISSN 1286-4579. E-ISSN 1769-714X
Institutional research plan: CEZ:AV0Z60220518
Keywords : Japanese encephalitis * Neurotropic infection * Neuropathogenesis * Mosquito borne infections * Arboviral infections
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.101, year: 2011
Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection.
Permanent Link: http://hdl.handle.net/11104/0197230
Number of the records: 1