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Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles

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    0359268 - FGÚ 2012 RIV US eng J - Journal Article
    Volkov, E. M. - Nurullin, L. F. - Volkov, M. E. - Nikolsky, E. E. - Vyskočil, František
    Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles.
    Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. Roč. 158, č. 4 (2011), s. 520-524. ISSN 1095-6433. E-ISSN 1531-4332
    R&D Projects: GA AV ČR(CZ) IAA500110905; GA ČR GA202/09/0806
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : GABA * acetylcholine * atropine
    Subject RIV: ED - Physiology
    Impact factor: 2.235, year: 2011

    This work was aimed to identify the action of several ion channel and pump inhibitors as well as nicotinic, GABAergic, purinergic and serotoninergic drugs on the resting membrane potential (RMP) and assess the role of cholinergic and GABAergic sensitivity in earthworm muscle electrogenesis. . The long-term application of CCh depolarizes the RMP primarily by inhibiting the Na+/K+-ATPase. The muscle membrane also contains A and B type GABA binding sites, the activation of which increases the RMP at the expense of increasing the action of ouabain- and Cl- -sensitive electrogenic pumps
    Permanent Link: http://hdl.handle.net/11104/0197081

     
     
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