Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission

0359223 - BC 2012 RIV AU eng J - Journal Article
Schwarz, Alexandra - Juarez, J. A. - Richards, J. - Rath, B. - Machaca, V. Q. - Castro, Y. E. - Málaga, E. S. - Levy, K. - Gilman, R. H. - Bern, C. - Verastegui, M. - Levy, M. Z.
Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission.
International Journal for Parasitology. Roč. 41, č. 6 (2011), s. 591-594. ISSN 0020-7519. E-ISSN 1879-0135
R&D Projects: GA ČR GPP302/11/P798
Institutional research plan: CEZ:AV0Z60220518
Keywords : Triatoma infestans * Impregnated net * Sentinel guinea pig * Saliva * Antibody response
Subject RIV: EC - Immunology
Impact factor: 3.393, year: 2011

Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.
Permanent Link: http://hdl.handle.net/11104/0197050