The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases

0359135 - ÚOCHB 2012 RIV GB eng J - Journal Article
Kovačková, Soňa - Dračínský, Martin - Rejman, Dominik
The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases.
Tetrahedron. Roč. 67, č. 7 (2011), s. 1485-1500. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠMT 2B06065; GA MZd NR9138; GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506
Keywords : piperidine derivatives * nucleoside analogs * nucleobase * proline
Subject RIV: CC - Organic Chemistry
Impact factor: 3.025, year: 2011

This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found.
Permanent Link: http://hdl.handle.net/11104/0196975