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Automatic Formation of Hypotheses on the Relationships between Structure of Naphthalene Analogs and Bioluminescence Response of Bioreporter Pseudomonas fluorescens HK44
- 1.0359054 - ÚCHP 2012 RIV CZ eng J - Journal Article
Trögl, J. - Hálová, J. - Kuncová, Gabriela - Pařík, P.
Automatic Formation of Hypotheses on the Relationships between Structure of Naphthalene Analogs and Bioluminescence Response of Bioreporter Pseudomonas fluorescens HK44.
Folia Microbiologica. Roč. 55, č. 5 (2010), s. 411-417. ISSN 0015-5632. E-ISSN 1874-9356
R&D Projects: GA MŠMT OC 121
Institutional research plan: CEZ:AV0Z40720504
Keywords : substituted naphthalenes * bioconversion * optical biosensor
Subject RIV: CE - Biochemistry
Impact factor: 0.977, year: 2010
Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.
Permanent Link: http://hdl.handle.net/11104/0196924
Number of the records: 1