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Sensing mispaired thymines in DNA heteroduplexes using an electroactive osmium marker: towards electrochemical SNP probing

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    0358994 - BFÚ 2012 RIV DE eng J - Journal Article
    Kostečka, Pavel - Havran, Luděk - Bittová, M. - Pivoňková, Hana - Fojta, Miroslav
    Sensing mispaired thymines in DNA heteroduplexes using an electroactive osmium marker: towards electrochemical SNP probing.
    Analytical and Bioanalytical Chemistry. Roč. 400, č. 1 (2011), s. 197-204. ISSN 1618-2642. E-ISSN 1618-2650
    R&D Projects: GA ČR GP203/08/P598; GA AV ČR IAA400040903; GA MŠMT LC06035; GA ČR(CZ) GAP206/11/1638
    Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Keywords : single-base mismatch * osmium tetroxide * electrochemistry
    Subject RIV: BO - Biophysics
    Impact factor: 3.778, year: 2011

    Complex of Os04 and 2,2-bipyridine (Os,bipy) was tested as a probe for distinction between a perfectly base-paired DNA homoduplexes and mismatched heteroduplexes, as well as discrimination among heteroduplexes containing one or two mispaired thymines.
    Permanent Link: http://hdl.handle.net/11104/0196877

     
     
Number of the records: 1  

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