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A “Cute” Desensitization of TRPV1
- 1.0358917 - FGÚ 2012 RIV NL eng J - Journal Article
Touška, Filip - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie
A “Cute” Desensitization of TRPV1.
Current Pharmaceutical Biotechnology. Roč. 12, č. 1 (2011), s. 122-129. ISSN 1389-2010. E-ISSN 1873-4316
R&D Projects: GA ČR GA305/09/0081; GA ČR(CZ) GAP301/10/1159; GA AV ČR(CZ) IAA600110701; GA MŠMT(CZ) 1M0517; GA MŠMT(CZ) LC554
Grant - others:Univerzita Karlova(CZ) 43-259 052
Institutional research plan: CEZ:AV0Z50110509
Keywords : capsaicin * analgesia * vanilloid receptor
Subject RIV: FH - Neurology
Impact factor: 2.805, year: 2011
Upon stimulation, the calcium influx via the vanilloid TRPV1 channels acutely desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic calcium overload. This review attempts to cover historical aspects of research into this process, tries to highlight some new challenging thoughts on the important phenomenon of TRPV1 desensitization and focuses on the putative molecular mechanisms that are thought to account for the acute phase of this process (‘acute desensitization’)
Permanent Link: http://hdl.handle.net/11104/0196825
Number of the records: 1