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Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats
- 1.0358912 - FGÚ 2011 RIV US eng J - Journal Article
Borchert, Gudrun H. - Yang, Ch. - Kolář, František
Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats.
American Journal of Physiology-Heart and Circulatory Physiology. Roč. 300, č. 2 (2011), H507-H513. ISSN 0363-6135. E-ISSN 1522-1539
R&D Projects: GA ČR(CZ) GA305/07/1008; GA AV ČR IAA500110804
Keywords : chronic hypoxia * ventricular myocytes * metabolic inhibition * cell viability * potassium channels
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 3.708, year: 2011
Chronic hypoxia reduced glycosylation level of the beta-1 regulatory subunit of the cardiac mitochondrial large-conductance calcium-activated potassium channels (BK). Ventricular myocytes isolated from chronically hypoxic rats retained the improved resistance against injury caused by simulated ischemia/reperfusion. The blunting effect of paxilline (BK inhibitor) and the absence of additive protection by NS-1619 (BK opener) suggest that chronic hypoxia leads to the activation of these channels, which contribute to the protective mechanism
Permanent Link: http://hdl.handle.net/11104/0196821
Number of the records: 1