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Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome
- 1.0358902 - FGÚ 2012 RIV US eng J - Journal Article
Pravenec, Michal - Kajiya, T. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Malínská, H. - Oliyarnyk, O. - Kazdová, L. - Fan, J. - Wang, J. - Kurtz, T. W.
Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome.
Hypertension. Roč. 57, č. 4 (2011), s. 731-737. ISSN 0194-911X. E-ISSN 1524-4563
R&D Projects: GA MZd(CZ) NS9759; GA MŠMT(CZ) ME08006; GA MŠMT(CZ) 1M0520; GA ČR(CZ) GAP301/10/0290; GA ČR GAP303/10/0505; GA AV ČR(CZ) IAA500110805
Grant - others:EC(XE) HEALTH-F4-2010-241504
Institutional research plan: CEZ:AV0Z50110509
Keywords : C-reactive protein * metabolic syndrome * transgenic rat
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 6.207, year: 2011
We sought to investigate whether increased levels of human CRP, per se, can promote increases in blood pressure and disturbances in glucose and lipid metabolism characteristic of the metabolic syndrome. To accomplish this goal, we transgenically expressed human CRP in the spontaneously hypertensive rat (SHR) and found that that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome
Permanent Link: http://hdl.handle.net/11104/0196813
Number of the records: 1