Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery

0358505 - ÚMCH 2012 RIV US eng J - Journal Article
Angelova, A. - Angelov, Borislav - Mutafchieva, R. - Lesieur, S. - Couvreur, P.
Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery.
Accounts of Chemical Research. Roč. 44, č. 2 (2011), s. 147-156. ISSN 0001-4842. E-ISSN 1520-4898
R&D Projects: GA ČR GA202/09/2078; GA ČR GAP208/10/1600
Institutional research plan: CEZ:AV0Z40500505
Keywords : lipid-water phases * liquid crystals * multicompartment lipid nanostructures
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 21.640, year: 2011

Lipids and lipopolymers self-assembled into biocompatible nano and mesostructured functional materials offer many potential applications in medicine and diagnostics. In this Account, it is demonstrated how high-resolution structural investigations of bicontinuous cubic templates made from lyotropic thermosensitive liquid-crystalline (LC) materials have initiated the development of innovative lipidopolymeric self-assembled nanocarriers. Such structures have tunable nanochannel sizes, morphologies, and hierarchical inner organizations and provide potential vehicles for the predictable loading and release of therapeutic proteins, peptides, or nucleic acids. This Account shows that structural studies of swelling of bicontinuous cubic lipid/water phases are essential for overcoming the nanoscale constraints for encapsulation of large therapeutic molecules in multicompartment lipid carriers.
Permanent Link: http://hdl.handle.net/11104/0196529