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Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
- 1.0358349 - BC 2012 RIV US eng J - Journal Article
Chmelař, Jindřich - Oliveira, C. J. - Řezáčová, Pavlína - Francischetti, I.M.B. - Kovářová, Zuzana - Pejler, G. - Kopáček, Petr - Ribeiro, J.M.C. - Mareš, Michael - Kopecký, Jan - Kotsyfakis, Michalis
Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
Blood. Roč. 117, č. 2 (2011), s. 736-744. ISSN 0006-4971. E-ISSN 1528-0020
R&D Projects: GA AV ČR IAA600960811; GA MŠMT(CZ) LC06009; GA ČR(CZ) GAP207/10/2183
Institutional research plan: CEZ:AV0Z60220518; CEZ:AV0Z40550506
Keywords : parasite serpin * IRS-2 * tick * Ixodes ricinus * platelet aggregation * inflammation * cathepsin G * chymase
Subject RIV: EC - Immunology
Impact factor: 9.898, year: 2011
A protein with antiinflammatory and anti-platelet effect was identified. It was named IRS-2 (Ixodes ricinus serpin – 2). It belongs into the group of serpins – inhibitors of serine proteases and the mode of action of IRS-2 derives from its inhibitory activity against cathepsin G and mast cell chymase. Antiinflammatory activity was shown using paw edema experiment with mice. IRS-2 inhibited specifically only cathepsin G and thrombin induced platelet aggregation.
Permanent Link: http://hdl.handle.net/11104/0196424
Number of the records: 1