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Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA

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    0358135 - BFÚ 2011 RIV GB eng J - Journal Article
    Malina, Jaroslav - Kašpárková, J. - Farrell, N.P. - Brabec, Viktor
    Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA.
    Nucleic Acids Research. Roč. 39, č. 2 (2011), s. 720-728. ISSN 0305-1048. E-ISSN 1362-4962
    R&D Projects: GA MŠMT(CZ) ME08017; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA MŠMT(CZ) ME10066
    Grant - others:GA MŠk(CZ) LC06030; GA MŠk(CZ) OC09018; GA AV ČR(CZ) KAN200200651
    Program: LC; KA
    Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Keywords : BBR3464 * DNA * cross-link
    Subject RIV: BO - Biophysics
    Impact factor: 8.026, year: 2011

    The results show that cross-links originally formed by BBR3464 in one strand of DNA can spontaneously translocate from one DNA strand to its complementary counterpart, which may evoke walking of the platinum complex on DNA molecule.
    Permanent Link: http://hdl.handle.net/11104/0196242

     
     
Number of the records: 1  

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