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Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway
- 1.0357770 - BFÚ 2011 RIV GB eng J - Journal Article
Vondálová Blanářová, Olga - Jelínková, Iva - Szoor, A. - Skender, Belma - Souček, Karel - Horváth, Viktor - Vaculová, Alena - Anděra, Ladislav - Sova, P. - Szollosi, J. - Hofmanová, Jiřina - Vereb, G. - Kozubík, Alois
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Carcinogenesis. Roč. 32, č. 1 (2011), s. 42-51. ISSN 0143-3334. E-ISSN 1460-2180
R&D Projects: GA ČR(CZ) GA301/07/1557; GA MZd NS9600
Grant - others:GA ČR(CZ) GD303/09/H048
Program: GD
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50520514
Keywords : TRAIL * platinum complexes * apoptosis
Subject RIV: BO - Biophysics
Impact factor: 5.702, year: 2011
Platinum complexes LA-12 and cisplatin enhanced TRAIL-induced apoptosis in colon and prostate cancer cells. They increased surface expression of DR5 receptor for TRAIL, which has been shown to be crucial for induction of apoptosis. Moreover, LA-12 and cisplatin mediated translocation of TRAIL receptors DR4 and DR5 to lipid rafts and enhanced internalization of TRAIL. These events modulated early steps of TRAIL, signaling and may contribute to induction of apoptosis.
Permanent Link: http://hdl.handle.net/11104/0195967
Number of the records: 1