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Mutant genetic background affects the functional rearrangement and kinetic properties of JMJD2b histone demethylase
- 1.0357399 - BFÚ 2011 RIV GB eng J - Journal Article
Bártová, Eva - Stixová, Lenka - Galiová-Šustáčková, Gabriela - Harničarová, Andrea - Legartová, Soňa - Kozubek, Stanislav
Mutant genetic background affects the functional rearrangement and kinetic properties of JMJD2b histone demethylase.
Journal of Molecular Biology. Roč. 405, č. 3 (2011), s. 679-695. ISSN 0022-2836. E-ISSN 1089-8638
R&D Projects: GA ČR(CZ) GAP302/10/1022
Grant - others:GA MŠk(CZ) LC06027; GA MŠk(CZ) LC535
Program: LC; LC
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : histone code * SUV39h * JMJ2b
Subject RIV: BO - Biophysics
Impact factor: 4.001, year: 2011
We have studied dynamics of JMJD2b histone demethylases, which functional characteristics are different in mutant and truncated variants. Important changes in nuclear distribution and kinetics of JMJD2b were observed in prostate cancer cells in comparison with other tumor cells and fibroblasts.
Permanent Link: http://hdl.handle.net/11104/0195685
Number of the records: 1