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Determination of Substitution Sites in Monosubstituted Five-Membered Aromatic Heterocycles
- 1.0357015 - ÚCHP 2012 RIV GB eng J - Journal Article
Schraml, Jan - Kubec, R. - Kučerová, P.
Determination of Substitution Sites in Monosubstituted Five-Membered Aromatic Heterocycles.
Magnetic Resonance in Chemistry. Roč. 49, č. 3 (2011), s. 147-150. ISSN 0749-1581. E-ISSN 1097-458X
R&D Projects: GA AV ČR IAA400720706
Institutional research plan: CEZ:AV0Z40720504
Keywords : pyrrole * 13c nmr * inadequate
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 1.437, year: 2011
Similar magnitudes of proton–proton couplings across three, four, and five bonds and proton–carbon couplings across two and three bonds combined with difficult to predict substituent effects make the results of an indiscriminate use of routine techniques for substitution sitedetermination in C-monosubstituted five-memberedheteroaromatics suspect. As demonstrated on two examples of natural products, the use of 1,1-ADEQUATE leads to unambiguous substitution site determination lending thus further support to suggested inclusion of 1,1-ADEQUATE data into computer-assisted structure elucidation (CASE) protocols.
Permanent Link: http://hdl.handle.net/11104/0195389
Number of the records: 1