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Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity
- 1.0356878 - BFÚ 2011 RIV SE eng J - Journal Article
Drábiková, K. - Perečko, T. - Nosál, R. - Račková, L. - Ambrožová, Gabriela - Lojek, Antonín - Šmidrkal, J. - Harmatha, Juraj - Jančinová, V.
Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.
Neuroendocrinology Letters. Roč. 31, č. 2 (2010), s. 73-78. ISSN 0172-780X. E-ISSN 2354-4716
R&D Projects: GA MŠMT(CZ) MEB0810013
Grant - others:GA ČR(CZ) GA203/07/1227
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z40550506
Keywords : reactive species * phagocytosis * coumarin
Subject RIV: BO - Biophysics
Impact factor: 1.621, year: 2010
Synthetic phenylcoumarin derivatives HHC (7-hydroxy-3-(4'-hydroxyphenyl) coumarin) and HHDC (7-hydroxy-3-(4'-hydroxyphenyl)-3,4-dihydrocoumarin) can affect ROS generation in human neutrophils and NO production by RAW 264.7 macrophages. The obtained results highlighted the different effects of HHC and HHDC on fagocyte functions, which might be due to their diverse free radical scavenging properties and lipophilicity features.
Permanent Link: http://hdl.handle.net/11104/0195286
Number of the records: 1