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CGG repeats associated with fragile X chromosome form left-handed Z-DNA structure
- 1.0356600 - BFÚ 2011 RIV US eng J - Journal Article
Renčiuk, Daniel - Kypr, Jaroslav - Vorlíčková, Michaela
CGG repeats associated with fragile X chromosome form left-handed Z-DNA structure.
Biopolymers. Roč. 95, č. 3 (2011), s. 174-181. ISSN 0006-3525. E-ISSN 1097-0282
R&D Projects: GA ČR(CZ) GA202/07/0094; GA AV ČR(CZ) IAA100040701
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : fragile X chromosome syndrome * Z-DNA * trinucleotide repeats
Subject RIV: BO - Biophysics
Impact factor: 2.870, year: 2011
In this work we demonstrate that CGG runs adopt a left-handed Z-DNA structure and its formation increased with increasing number of repeats. We show here that methylation of the (CGG) runs markedly stabilized Z-DNA formation.
Permanent Link: http://hdl.handle.net/11104/0195084
Number of the records: 1