Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death

0356581 - BC 2011 RIV GB eng J - Journal Article
Zuberová, M. - Fencková, M. - Šimek, Petr - Janečková, L. - Doležal, T.
Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death.
Disease Models & Mechanisms. Roč. 3, 11/12 (2010), s. 773-784. ISSN 1754-8403. E-ISSN 1754-8411
R&D Projects: GA ČR(CZ) GD204/09/H058
Grant - others:AV ČR(CZ) KJB501410602; GA ČR(CZ) GA204/09/1463
Institutional research plan: CEZ:AV0Z50070508
Keywords : central nervous system * glycogen phosphorylase * immune response
Subject RIV: CE - Biochemistry
Impact factor: 4.584, year: 2010

Extracellular adenosine is an important signaling molecule in neuromodulation, immunomodulation and hypoxia. Adenosine dysregulation can cause various pathologies, exemplified by a deficiency in adenosine deaminase in severe combined immunodeficiency. We have established a Drosophila model to study the effects of increased adenosine in vivo by mutating the main Drosophila adenosine deaminase-related growth factor (ADGF-A). Using a genetic screen, we show here that the increased extracellular adenosine in the adgf-a mutant is associated with hyperglycemia and impairment in energy storage. The adenosine works in this regard through the adenosine receptor as an anti-insulin hormone in parallel to adipokinetic hormone, a glucagon counterpart in flies. If not regulated properly, this action can lead to a loss of energy reserves (wasting) and death of the organism.
Permanent Link: http://hdl.handle.net/11104/0195071